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Anti Active Rap1 Mouse Monoclonal Antibody - USA

price: contact company for price

Catalog Number: 26912

Gene Symbol: RAP1

Description: Anti-Active Rap1 Mouse Monoclonal Antibody

Background: Small GTPases are a super-family of cellular signaling regulators. Rap family members (Rap1A, Rap1B, Rap2A, Rap2B, and Rap2C) are Ras-like GTPases that regulate cell proliferation, differentiation, apoptosis and adhesion mechanisms. Rap1 (Ras-proximate-1) regulates apoptosis through interaction with two MAP3K effectors of the MEK/ERK MAP-kinase pathway, Raf-1 and B-Raf. Rap1 regulates cell adhesion mechanisms through effector molecules such as the integrins and cadherins.

Immunogen: Recombinant full length protein of active Rap1.

Applications: IP, IHC

Recommended Dilutions: 1 μg for 1~2 mg total cellular proteins for IP

1:100 dilution for IHC

Concentration: 1 mg/ml

Host: mouse

Format: Liquid

Clonality: Monoclonal

Isotype: IgG

Purity: Purified from ascites

Storage buffer:

Preservative: no

Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol

Species Reactivity: Anti-active Rap1 antibody recognizes active Rap1 of vertebrates.

Storage Conditions: Store at -20°C. Avoid freeze / thaw cycles

Company Contact:

  • Phone: 6109452007

  • Address: 24 Whitewoods Lane, Malvern, PA, USA

  • Email: Email

Published date: June 6, 2013 -

  • Business Description: NewEast Biosciences are specialized in generating protein configuration specific monoclonal antibodies that recognize active (GTP bound) G proteins (including Ras superfamily small GTPases and heterotrimeric G proteins). These unique antibodies do not recognize the inactive (GDP bound) G proteins. These monoclonal antibodies have been successfully used to immunoprecipitate active G proteins from cell lysates, and for immunohistochemical staining of active G proteins in cultured cells or in tissue sections. Hence, these antibodies can be used to study the spatial and temporal dynamics of cellular signaling involving big and small G proteins, the future direction of signal transduction studies.

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