Anti Atm F858l Mouse Monoclonal Antibody - USAprice: contact company for price
Gene Symbol: ATM
Description: Anti-ATM (F858L) Mouse Monoclonal Antibody
Background: Ataxia telangiectasia mutated (ATM) is a serine/threonine protein kinase that is recruited and activated by DNA double-strand breaks. It phosphorylates several key proteins that initiate activation of the DNA damage checkpoint, leading to cell cycle arrest, DNA repair or apoptosis. Activity of ATM protein is under tight control, and mutation of ATM can cause disease such as Ataxia telangiectasia (AT) and cancers.
Immunogen: A synthetic peptide from the internal region of ATM which includes the mutation of F858L, human origin.
Applications: ELISA, WB, IHC
Concentration: 1 mg/ml
Purity: Purified from ascites
Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol
Species Reactivity: Recognizes ATM (F858L), but not wild type ATM protein from vertebrates.
Storage Conditions: Store at -20°C. Avoid freeze / thaw cycles
- Posted By: NewEast Biosciences
- Phone: 6109452007
- Address: 24 Whitewoods Lane, Malvern, PA, USA
- Website: http://neweastbio.com
Published date: June 6, 2013 -
- Business Description: NewEast Biosciences are specialized in generating protein configuration specific monoclonal antibodies that recognize active (GTP bound) G proteins (including Ras superfamily small GTPases and heterotrimeric G proteins). These unique antibodies do not recognize the inactive (GDP bound) G proteins. These monoclonal antibodies have been successfully used to immunoprecipitate active G proteins from cell lysates, and for immunohistochemical staining of active G proteins in cultured cells or in tissue sections. Hence, these antibodies can be used to study the spatial and temporal dynamics of cellular signaling involving big and small G proteins, the future direction of signal transduction studies.
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