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Anti Erbb2 V777a Mouse Monoclonal Antibody - USA

price: contact company for price

Catalog Number: 26080

Gene Symbol: ERBB2/HER2/Neu

Description: Anti-ErbB2 (V777A) mouse monoclonal Antibody

Background: The ErbB family is composed of four plasma membrane-bound receptor tyrosine kinases. Amplification or over-expression of the ERBB2 gene occurs in approximately 30% of breast cancers. HER2 is encoded by ERBB2, a known proto-oncogene located at the long arm of human chromosome 17(17q21-q22). HER2 proteins have been shown to form clusters in cell membranes that may play a role in tumorigenesis. Mutations of ErbB2 protein, including V777A, have been indicated in human cancers.

Immunogen: A synthetic peptide surround the 777A codon of ErbB2 protein.

Tested Applications: ELISA, WB, IF, IHC

Recommended Dilutions:

ELISA: 1:500-1:5000

WB: 1:200-1:2000

IF: 1:100

IHC: 1:50-1:100

Concentration: 0.2 mg/ml

Host: mouse

Format: Liquid

Clonality: Monoclonal


Purity: Purified from ascites

Storage buffer:

Preservative: no

Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol

Species Reactivity: Recognizes V777A mutant but not wild type ErbB2 protein, of vertebrates.

Storage Conditions: Store at -20°C. Avoid freeze / thaw cycles.

Company Contact:

  • Phone: 6109452007

  • Address: 24 Whitewoods Lane, Malvern, PA, USA

  • Email: Email

Published date: June 6, 2013 -

  • Business Description: NewEast Biosciences are specialized in generating protein configuration specific monoclonal antibodies that recognize active (GTP bound) G proteins (including Ras superfamily small GTPases and heterotrimeric G proteins). These unique antibodies do not recognize the inactive (GDP bound) G proteins. These monoclonal antibodies have been successfully used to immunoprecipitate active G proteins from cell lysates, and for immunohistochemical staining of active G proteins in cultured cells or in tissue sections. Hence, these antibodies can be used to study the spatial and temporal dynamics of cellular signaling involving big and small G proteins, the future direction of signal transduction studies.

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