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Cd163 Antibody - China
price: 299.00 Dollar US$
Product Name: CD163 Antibody
Code : CSB-RA801238A0HU
Abbreviation : Scavenger receptor cysteine-rich type 1 protein M130
Storage : Upon receipt, store at -20°C or -80°C.
Avoid repeated freeze.
Immunogen : A synthesized peptide
Species Reactivity : Human
Tested Applications : ELISA, IHC, FC; Recommended dilution: IHC: 1: 50-1: 500
Relevance : Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage.
May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme.
Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner.
Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype.
Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1 - Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.
After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.
Form : Liquid
Conjugate : Non-conjugated
Storage Buffer : Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification method : Affinity-chromatography
Isotype : Rabbit IgG
Clonality : Monoclonal
Alias : Scavenger receptor cysteine-rich type 1 protein M130, Hemoglobin scavenger receptor, CD163, Soluble CD163, sCD163, CD163, M130
Species : Human
Research Area : Immunology
Company Contact:
- Posted By: Cusabio Biotech Co., Ltd
- Phone: 862787582341
- Address: Building B11, #818 Gaoxin Road, Wuhan , China
- Email:
- Website: https://www.cusabio.com
Published date: December 20, 2017
- Business Description: CUSABIO is a leading biotechnology company specialized in production of
high quality products for gene, protein, antibody, ELISA kit, raw
material for production of diagnostic kit, drug residues, food safety
small molecules & other small molecules.
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