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Recombinant Human Abhydrolase Domain Containing 4 His Tagged - China

price: contact company for price

Abhydrolase domain-containing protein 4, also known as Lyso-N-

acylphosphatidylethanolamine lipase, Alpha/beta-hydrolase 4 and ABHD4,

is a protein which belongs to the peptidase S33 family and ABHD4 / ABHD5

subfamily. The alpha/beta hydrolase fold is common to a number of

hydrolytic enzymes of widely differing phylogenetic origin and catalytic

function. The core of each enzyme is an alpha/beta-sheet (rather than a

barrel), containing 8 strands connected by helices. The enzymes are

believed to have diverged from a common ancestor, preserving the

arrangement of the catalytic residues. All have a catalytic triad, the

elements of which are borne on loops, which are the best-conserved

structural features of the fold. ABHD4 lysophospholipase selective for

N-acyl phosphatidylethanolamine (NAPE). ABHD4 contributes to the

biosynthesis of N-acyl ethanolamines, including the endocannabinoid

anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl

phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl

ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine

biosynthesis. ABHD4 hydrolyzes substrates bearing saturated,

monounsaturated, polyunsaturated N-acyl chains.


Company Contact:


  • Phone: 15166698109

  • Address: 45-16 Ramsey Road Shirley, NY 11967, USA, New York, China

  • Email: Email


Published date: June 28, 2013 -

  • Business Description: involved in international trade import export of goods, products, and services

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