Anti Egfr L747 P753 S Mouse Monoclonal Antibody - USAprice: contact company for price
Gene Symbol: EGFR/ HER1/ ERBB1
Description: Anti- EGFR ( L747- P753) S Mouse Monoclonal Antibody
Background: EGFR is a receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. It activates at least 4 major downstream signaling cascades including the RAS- RAF- MEK- ERK, PI3 kinase- AKT, PLCgamma- PKC and STATs modules. Defects in EGFR are associated with lung cancer ( LNCR) .
Immunogen: A synthetic peptide from the internal region of EGFR which includes the mutation of ( L747- P753) S, human origin.
Applications: ELISA, WB, IF, IHC
ELISA: 1: 1000- 1: 5000
WB: 1: 500- 1: 1000
IHC: 1: 50- 1: 100
Concentration: 1 mg/ ml
Purity: Purified from ascites
Constituents: PBS ( without Mg2+ and Ca2+) , pH 7.4, 150 mM NaCl, 50% glycerol
Species Reactivity: Recognizes EGFR ( L747- P753) S, but not wild type EGFR protein from vertebrates.
Storage Conditions: Store at - 20°C. Avoid freeze / thaw cycles
- Posted By: NewEast Biosciences
- Phone: 6109452007
- Address: 24 Whitewoods Lane, Malvern, PA, USA
- Website: http://neweastbio.com
Published date: March 11, 2015 -
- Business Description: NewEast Biosciences are specialized in generating protein configuration specific monoclonal antibodies that recognize active (GTP bound) G proteins (including Ras superfamily small GTPases and heterotrimeric G proteins). These unique antibodies do not recognize the inactive (GDP bound) G proteins. These monoclonal antibodies have been successfully used to immunoprecipitate active G proteins from cell lysates, and for immunohistochemical staining of active G proteins in cultured cells or in tissue sections. Hence, these antibodies can be used to study the spatial and temporal dynamics of cellular signaling involving big and small G proteins, the future direction of signal transduction studies.
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