2 Methyl 5 Nitropyridin 3 Amine Cas 51984 61 - Chinaprice: contact company for price
2- methyl- 5- nitropyridin- 3- amine is an intermediate for Flumatinib, an antineoplastic tyrosine kinase inhibitor used for the treatment of chronic myelogenous leukemia ( CML) .
Brief introduction of Flumatinib
The chemical name of Flumatinib is 4- ( 4- Methyl- piperazin- 1- ylmethyl) - N- [ 6- methyl- 5- ( 4- pyridin- 3- yl- pyrimidin- 2- ylamino) - pyridin- 3- yl] - 3- trifluoromethyl- benzamide. Its molecular formula is C29H29F3N8O. Currently in China, it is at Phase I clinical trials for the treatment of chronic myelogenous leukemia ( CML) .
Chronic myelogenous leukemia ( CML) is a chronic myeloproliferative disease characterized by an overproduction of immature myeloid cells and mature granulocytes. CML is developed by the Philadelphia chromosome, a reciprocal chromosome translocation t( 9; 22) , which causes a constitutive activation of the BCR- ABL tyrosine kinase ( Deininger et al. , 2000; Ren 2005) . As a result, current CML treatment strategies involve the use of tyrosine kinase inhibitors, such as imatinib ( Chemical name 4- ( 4- methyl- piperazin- 1- ylmethyl) - N- [ 4- methyl- 3- ( 4- pyridin- 3- yl- pyrimidin- 2- ylamino) - phenyl] - benzamide) , nilotinib, and dasatinib ( Sawyers, 2001; Kantarjian et al. , 2006; Steinberg, 2007) .
Flumatinib is like imatinib in structure, but nonclinical studies have shown that Flumatinib was predominantly metabolized by amide bond cleavage to yield two corresponding hydrolytic products. By comparison with imatinib, the electron- withdrawing groups of trifluoromethyl and pyridine facilitated the amide bond cleavage and led to the in vivo formation of a carboxylic acid and an amine. Therefore, Flumatinib is more potent in vitro and in vivo activity than imatinib when tested against leukemia cells expressing BCR- ABL ( Sun et al. , 2008) .
- Posted By: Banff Green Technologies, Inc.
- Phone: 862154795870
- Address: Floor 29, CapitaMalls Plaza, No. 6088 Humin Rd., Shanghai, China
- Website: http://www.banffgt.com/
Published date: March 9, 2015 -
- Business Description: Banff Green Technologies, Inc. is a technologically innovative company
that focuses on chemicals, materials, pharmaceuticals, crop science and
environmental technology. The company headquarter is based in Shanghai,
China. Our research and development team is comprised of a talented and
experienced team of PhD s with strong scientific backgrounds dedicated
to our mission. We are also supported by strong infrastructure, which
include state of the art lab facilities, two pilot facilities and seven
manufacturing sites located in five provinces in China.
Our core businesses span over the following areas: R & D, production and sales of fine and specialty chemicals, contract manufacturing services and custom synthesis.
Our main products are: fluorinated fine chemicals (mainly Diethyl fluoromalonate and 5 fluorine pyrimidine derivatives), chiral compounds (amino acids and their derivatives, in particular D 2 Aminobutyric acid, L 2 Aminobutanamide hydrochloride, chloramphenicol and Valnemulin hydrochloride).
Our corporate mission is to achieve environmental protection and sustainability while being socially responsible through our research and innovation. We sincerely hope to better serve our customers through every facets of their needs and together we can achieve a more sustainable future.
4 5 6 Trifluoropyrimidine Cas 17573 78 3Chemicals - Other - Banff Green Technologies, Inc. - China - March 9, 2015 - contact company for price
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