4 Chloro 6 Ethyl 5 Fluoropyrimidine Cas 137234 74 3 - Chinaprice: contact company for price
4- chloro- 6- ethyl- 5- fluoropyrimidine is a building block and pharmaceutical intermediate for synthetizing bio- active compounds such as broad- spectrum triazole antifungal agents, specifically for producing Voriconazole.
Brief introduction of Voriconazole
Voriconazole, brand name Vfend, Pfizer, is in the forms of an injectable formulation [ 200 mg per vial] , solid oral formulations as 50 mg and 200 mg tablets and an oral suspension containing 200 mg of voriconazole/ 5 ml.
Voriconazole is a triazole antifungal medication generally used in the treatment of serious invasive fungal infections, including invasive candidiasis, invasive aspergillosis, and certain emerging fungal infections. Patients with these synptoms are generally immunocompromised. Voriconazole can also be used to treat severe invasive fluconazole- resistant Candida infections ( including C. krusei) and severe fungal infections with scedosporium spp. and Fusarium spp.
Application of 4- chloro- 6- ethyl- 5- fluoropyrimidine for synthetizing Voriconazole
Voriconazole is synthetized in a process of condensing 1- ( 2, 4- difluorophenyl) - 2- ( 1H- 1, 2, 4- triazole- 1- yl) ethanone with 4- chloro- 6- ethyl- 5- fluoropyrimidine, in a ketone, ether, aliphatic hydrocarbon, or aromatic hydrocarbon solvent, to obtain ( 2R, 3S/ 2S, 3R) - 3- ( 4- chloro- 5- fluoropyrimidin- 6- yl) - 2- ( 2, 4- diflurophenyl) - 1- ( 1H- 1, 2, 4- triazole- 1- yl) butan- 2- ol.
Preparation of 4- chloro- 6- ethyl- 5- fluoropyrimidine
Dissolve 80 g of 6- ethyl~5- fluoro- 4- hydroxypyrimidine in 240 ml of dichloromethane to get a solution. Add 78.24 ml of triethylamine to the solution and slowly add 57.4 ml of phosphorus oxychloride thereto for more than 30 minutes. After refluxing the resulting solution for 5 hours, the reaction is completed. Cool the solution to room temperature. After that, add 352 ml of 3N HCl to the solution. The temperature should be maintained at below 200 degrees . Extract the resulting liquid mixture with 100 ml of dichloromethane. Wash the organic layer with 100 ml of water, dry it over magnesium sulfate, and concentrate it under a reduced pressure to obtain the title compound in the form of oil. There is 85.9 g of the product and the yield is 95% .
Storage of 4- chloro- 6- ethyl- 5- fluoropyrimidine: Store under room temperature.
- Posted By: Banff Green Technologies, Inc.
- Phone: 862154795870
- Address: Floor 29, CapitaMalls Plaza, No. 6088 Humin Rd., Shanghai, China
- Website: http://www.banffgt.com/
Published date: April 20, 2015 -
- Business Description: Banff Green Technologies, Inc. is a technologically innovative company
that focuses on chemicals, materials, pharmaceuticals, crop science and
environmental technology. The company headquarter is based in Shanghai,
China. Our research and development team is comprised of a talented and
experienced team of PhD s with strong scientific backgrounds dedicated
to our mission. We are also supported by strong infrastructure, which
include state of the art lab facilities, two pilot facilities and seven
manufacturing sites located in five provinces in China.
Our core businesses span over the following areas: R & D, production and sales of fine and specialty chemicals, contract manufacturing services and custom synthesis.
Our main products are: fluorinated fine chemicals (mainly Diethyl fluoromalonate and 5 fluorine pyrimidine derivatives), chiral compounds (amino acids and their derivatives, in particular D 2 Aminobutyric acid, L 2 Aminobutanamide hydrochloride, chloramphenicol and Valnemulin hydrochloride).
Our corporate mission is to achieve environmental protection and sustainability while being socially responsible through our research and innovation. We sincerely hope to better serve our customers through every facets of their needs and together we can achieve a more sustainable future.
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