L 2 Aminobutanamide Hydrochloride 7682 20 4 - Chinaprice: contact company for price
L- 2- Aminobutanamide hydrochloride is a chemical usually used as the chemical reagent and intermediate, such as being the intermediate for Levetiracetam, a medicine resisting epilepsia and convulsions.
Levetiracetam, with the chemical name ( S) - 2- ( 2- Oxopyrrolidin- 1- yl) butanamide, is currently the only epilepsia resisting medicine that has been proven to combine with the synaptin SV2A inside the presynaptic nerve terminal. It can restrain the abnormal electro- discharge in the epilepsia loop, and therefore block the seizures. It is used in the treatment of partial, secondary and general epilepsia.
The structure of Levetiracetam is similar to that of Piracetam. It was manufactured by UCB Pharmaceuticals Inc. , a Belgium company. In April 2000, Levetiracetam became available as a generic drug in the United States. Nowadays, it is marketed in many countries as an internationally- recognized new generation broad spectrum epilepsia resisting medicine.
Compared with most other epilepsia resisting medicine, Levetiracetam shows stronger efficacy in resisting epilepsia. Not only its therapeutic index is high, but also its pharmacokinetics property is quite unique. Taken orally, Levetiracetam works fast and is safe. The bioavailability is as high as 100% .
Preparation of L- 2- Aminobutanamide hydrochloride
Comprising reacting ( S) - 2- aminobutyric acid hydrochloride with thionyl chloride to form an intermediate, reacting the intermediate with ammonia to form L- 2- Aminobutanamide hydrochloride.
Synthesis of Levetiracetam from L- 2- Aminobutanamide hydrochloride
Using L- 2- Aminobutanamide hydrochloride as the chiral source, the resolution of raceme could be avoided.
A feasible industrialized preparation way for Levetiracetam
Late Ring Closure route
Using L- 2- Aminobutanamide hydrochloride as the starting raw material, comprising reacting with SOCl2 and get acyl chloride, and then esterification reacting with methanol or ethanol to get amino ester. Through the intermolecular nucleophilic substitution between amino ester and ethyl- 4- bromo butyrate, get an intermediate that after separation and purification, and with the existence of 2- Hydroxy Pyrimidine, get ( S) - PBM by closing loop. Then through the aminolysis reaction, convert the ester into acid amides and get Levetiracetam.
Storage of L- 2- Aminobutanamide hydrochloride
L- 2- Aminobutanamide hydrochloride should be kept at the temperature of 2- 8°C.
The Advantages of BGT for L- 2- Aminobutanamide hydrochloride production
We offer the best price on the market due to our advanced process.
Our L- 2- Aminobutanamide hydrochloride can reach as high as 99% chemical and optical purity ( by HPLC) , and is the highest assay that is commercially available. The common purity of L- 2- Aminobutanamide hydrochloride on the market is less than 98% chemically and less than 96% optically.
As L- 2- Aminobutanamide hydrochloride is one of Banff’s most important products, a large stock is available all year round.
Safe production process, environmental friendly, sustainable development.
- Posted By: Banff Green Technologies, Inc.
- Phone: 862154795870
- Address: Floor 29, CapitaMalls Plaza, No. 6088 Humin Rd., Shanghai, China
- Website: http://www.banffgt.com/
Published date: March 9, 2015 -
- Business Description: Banff Green Technologies, Inc. is a technologically innovative company
that focuses on chemicals, materials, pharmaceuticals, crop science and
environmental technology. The company headquarter is based in Shanghai,
China. Our research and development team is comprised of a talented and
experienced team of PhD s with strong scientific backgrounds dedicated
to our mission. We are also supported by strong infrastructure, which
include state of the art lab facilities, two pilot facilities and seven
manufacturing sites located in five provinces in China.
Our core businesses span over the following areas: R & D, production and sales of fine and specialty chemicals, contract manufacturing services and custom synthesis.
Our main products are: fluorinated fine chemicals (mainly Diethyl fluoromalonate and 5 fluorine pyrimidine derivatives), chiral compounds (amino acids and their derivatives, in particular D 2 Aminobutyric acid, L 2 Aminobutanamide hydrochloride, chloramphenicol and Valnemulin hydrochloride).
Our corporate mission is to achieve environmental protection and sustainability while being socially responsible through our research and innovation. We sincerely hope to better serve our customers through every facets of their needs and together we can achieve a more sustainable future.
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