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  • Medical Biodegradable Ploymer Poly L Lactide Co Glycolide - China

    price: contact company for price

    Name : Poly(L-lactide-co-glycolide)

    Product Model : PLG

    Chemical Formula: (C6H8O4)m (C4H4O4)n

    CAS : 30846-39 -0

    Chemical Structure :

    Instructions: The alternate name of poly(L-lactide-co-

    glycolide) (PLGA), is polylactic acid-glycollic acid

    copolymer. PLGA is produced from lactic acid and glycolic

    acid. It is non-toxic and has excellent biodegradability,

    biocompatibility, film or capsule forming ability. PLGA is

    widely used in pharmaceutical, medical engineering materials

    and modern industrial fields. In the United States, PLGA has

    been approved by the FDA and is formally included in the

    United States pharmacopoeia as pharmaceutical materials.

    PLGA is a amorphous polymer. The glass transition

    temperature (Tg) of PLGA is 40 - 60 °C. It has been widely

    used in medical surgical sutures, anti-adhesion membrane,

    tissue engineering scaffolds and so on. The degradation rate

    of PLGA increases with the increase of GA proportion.

    Different types of PLGA can be produced using

    differentmonomer ratio . For example, PLGA 75:25 indicates

    that the polymer consists of 75% lactic acid and 25%

    glycolic acid.

    The degradation products of PLGA are lactic acid and

    glycolic acid, so they do not have toxic side effects when

    used as the pharmaceutical and biological materials. PLGA

    has been widely used in biomedical fields, such as medical

    anti-adhesion membrane, skin graft, stitched wound,

    injectable microcapsules, microspheres, implants, scaffolds

    for tissue engineering.

    Appearance : White pale yellow powder or particles

    L- lactide / Glycolic (mol/mol) : 90/10, 80/20, 75/25,

    70/30, 50/50

    IV (Intrinsic viscosity): 0.2-1.8 dL/g

    Specific Rotation( ,chloroform): ≤ -50°

    Glass Transition Temperature : 40-60°C

    Melting point : Amorphous

    Residual Monomers : < 1%

    Residual Solvents : < 0.05%

    Extractable Heavy Metals : <10 ppm

    Stannum (Catalyst) : < 200 ppm

    Density : 1.25 g/cm3

    Sulfate Ash : < 0.05%

    Model

    Model Ratio LA/GA IV LA/GA Proportional Range

    IV Range

    dL/g

    PLG90-03 90/10 0.3 87/13-93/7 0.20-0.40

    PLG90-05 90/10 0.5 87/13-93/7 0.40-0.70

    PLG90-08 90/10 0.8 87/13-93/7 0.70-1.00

    PLG90-12 90/10 1.2 87/13-93/7 1.00-1.40

    PLG90-16 90/10 1.6 87/13-93/7 1.40-1.80

    PLG90-20 90/10 2.0 87/13-93/7 >1.80

    PLG80-03 80/20 0.3 77/23-83/17 0.20-0.40

    PLG80-05 80/20 0.5 77/23-83/17 0.40-0.70

    PLG80-08 80/20 0.8 77/23-83/17 0.70-1.00

    PLG80-12 80/20 1.2 77/23-83/17 1.00-1.40

    PLG80-16 80/20 1.6 77/23-83/17 1.40-1.80

    PLG80-20 80/20 2.0 77/23-83/17 >1.80

    PLG75-03 75/25 0.3 72/28-78/22 0.20-0.40

    PLG75-05 75/25 0.5 72/28-78/22 0.40-0.70

    PLG75-08 75/25 0.8 72/28-78/22 0.70-1.00

    PLG75-12 75/25 1.2 72/28-78/22 1.00-1.40

    PLG75-16 75/25 1.6 72/28-78/22 1.40-1.80

    PLG75-20 75/25 2.0 72/28-78/22 >1.80

    PLG70-03 70/30 0.3 67/33-73/27 0.20-0.40

    PLG70-05 70/30 0.5 67/33-73/27 0.40-0.70

    PLG70-08 70/30 0.8 67/33-73/27 0.70-1.00

    PLG70-12 70/30 1.2 67/33-73/27 1.00-1.40

    PLG70-16 70/30 1.6 67/33-73/27 1.40-1.80

    PLG70-20 70/30 2.0 67/33-73/27 >1.80

    PLG50-03 50/50 0.3 47/53-53/47 0.20-0.40

    PLG50-05 50/50 0.5 47/53-53/47 0.40-0.70

    PLG50-08 50/50 0.8 47/53-53/47 0.70-1.00

    PLG50-12 50/50 1.2 47/53-53/47 1.00-1.40

    PLG50-16 50/50 1.6 47/53-53/47 1.40-1.80

    PLG50-20 50/50 2.0 47/53-53/47 >1.80


    Company Contact:


    • Phone: 15848782739

    • Address: No. 666A Chaoqun Street, High-tech Industrial Deve, JILIN, China

    • Email: Email


    Published date: April 7, 2013 -

    • Business Description: Changchun SinoBiomaterials Co., Ltd was founded in April 2007, High Tech

      Enterprises. It is mainly engaged in the manufacture of biodegradable

      polymer materials for medical applications, as well as the development

      and industrialization of the downstream products, such as L lactide (L

      LA), glycolic acid (GA), poly(L lactic acid) (PLLA), poly(glycolic acid)

      (PGA), poly(ε caprolactone) (PCL), monomethoxyl poly(ethylene glycol) b

      poly(lactic acid)(mPEG PLA) , Poly(D,L lactide) (PDLLA) and their

      copolymers, as well as absorbable internal fixation devices for fracture

      including bone screws and bone plates, tissue engineering scaffolds for

      bone repair, materials for sustained drug delivery, etc.

      Our company occupies an area of 10,000 meter square with a total investment of 33.55 million yuan. There are an integrated experimental building and a production workshop in accordance with GMP standards, both occupying 3,500 meter square. Over 90% of the employees in our company hold college degrees. The main management staffs have studied aboard for years. They have profound scientific attainments and abundant experience of management. With their expertise in chemical, biological and medical fields, our main technical staffs have strong capability for innovation and development of relative products.

      Changchun SinoBiomaterials Co., Ltd is technically supported by Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences. The Science and Technology Innovation Centre for poly(lactic acid) based biodegradable materials of Jilin Province and the Science and Technology Innovation Centre for poly(lactic acid) based biomaterials of Changchun City were founded jointly by SinoBiom and CIAC in 2007 and 2009, respectively. The foundation of these two research centres has been promoting the application of Medical biodegradable polymer materials in the medicine field and continuing to promote the pace of industrialization, with the goal of achieving the integration of production and studying and research.

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