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  • Npc2 Antibody Biotin Conjugated - China

    price: contact company for price

    Product Name:
    NPC2 Antibody;Biotin conjugated
    Code : CSB-PA015976LD01HU
    Size : US$166
    Uniprot NO. : P61916
    Storage : Shipped at 4°C Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
    Immunogen : Recombinant human Epididymal secretory protein E1 protein
    Raised in : Rabbit
    Species Reactivity : Human
    Tested Applications : ELISA;Not yet tested in other applications.
    Relevance : Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular \'tag team duo\' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pocket of the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket and is exported from the limiting membrane of late endosomes/ lysosomes to the ER and plasma membrane by an unknown mechanism. The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport.
    Form : Liquid
    Conjugate : Biotin
    Storage Buffer : Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
    Isotype : IgG
    Clonality : Polyclonal
    Alias : Epididymal secretory protein E1, NPC2, HE1, Human epididymis-specific protein 1, He1, Niemann-Pick disease type C2 protein

    Company Contact:

    • Phone: 862787582341

    • Address: Building B11, #818 Gaoxin Road, Wuhan, China

    • Email: Email

    Published date: June 3, 2016 -

    • Business Description: CUSABIO is a leading biotechnology company specialized in production of

      high quality products for gene, protein, antibody, ELISA kit, raw

      material for production of diagnostic kit, drug residues, food safety

      small molecules & other small molecules.

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