Anti Ctnnb1 G34v Mouse Monoclonal Antibody - USAprice: contact company for price
Gene Symbol: Beta- catenin, CTNNB, Catenin beta- 1
Description: Anti- CTNNB1 ( G34V) Mouse Monoclonal Antibody
Background: CTNNB1 protein is a dual function protein. It is a subunit of a complex of proteins that from adherens junctions, which are important for the establishment and maintenance of epithelial cell layers by regulating cell growth and adhesion between adjacent cells. CTNNB1 protein also pulls double duty as an intracellular signal transducer in the Wnt signaling pathway. Mutant CTNNB1 ( ß- catenin) has been implicated in the pathogenesis of several cancers including melanoma, colorectal cancer, hepatocelluar carcinoma, and ovarian cancerMutations of CTNNB1 have been implicated in the pathogenesis of several cancers.
Immunogen: A synthetic peptide from the internal region of CTNNB1 which includes the mutation of G34V, human origin.
Applications: ELISA, WB, IHC
ELISA: 1: 1000- 1: 2000
WB: 1: 500- 1: 1000
IHC: 1: 50- 1: 100
Concentration: 0.5 mg/ ml
Purity: Purified from ascites
Constituents: PBS ( without Mg2+ and Ca2+) , pH 7.4, 150 mM NaCl, 50% glycerol
Species Reactivity: Recognizes G34V mutant, but not wild- type CTNNB1 of vertebrates.
Storage Conditions: Store at - 20°C. Avoid freeze / thaw cycles
- Posted By: NewEast Biosciences
- Phone: 6109452007
- Address: 24 Whitewoods Lane, Malvern, PA, USA
- Website: http://neweastbio.com
Published date: March 11, 2015 -
- Business Description: NewEast Biosciences are specialized in generating protein configuration specific monoclonal antibodies that recognize active (GTP bound) G proteins (including Ras superfamily small GTPases and heterotrimeric G proteins). These unique antibodies do not recognize the inactive (GDP bound) G proteins. These monoclonal antibodies have been successfully used to immunoprecipitate active G proteins from cell lysates, and for immunohistochemical staining of active G proteins in cultured cells or in tissue sections. Hence, these antibodies can be used to study the spatial and temporal dynamics of cellular signaling involving big and small G proteins, the future direction of signal transduction studies.
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