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Anti Egfr E746 A750 Del Mouse Monoclonal Antibody - USA

price: contact company for price

Catalog Number: 26235

Gene Symbol: EGFR/ HER1/ ERBB1

Description: Anti- EGFR ( E746- A750) del Mouse Monoclonal Antibody

Background: EGFR is a receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. It activates at least 4 major downstream signaling cascades including the RAS- RAF- MEK- ERK, PI3 kinase- AKT, PLCgamma- PKC and STATs modules. Defects in EGFR are associated with lung cancer ( LNCR) .

Immunogen: A synthetic peptide from the internal region of EGFR which includes the deletion of E746- A750, human origin.

Applications: ELISA, WB

Recommended Dilutions:

ELISA: 1: 1000- 1: 5000

WB: 1: 500- 1: 1000

Concentration: 1 mg/ ml

Host: Mouse

Format: Liquid

Clonality: Monoclonal

Isotype:

Purity: Purified from ascites

Storage buffer:

Preservative: no

Constituents: PBS ( without Mg2+ and Ca2+) , pH 7.4, 150 mM NaCl, 50% glycerol

Species Reactivity: Recognizes EGFR ( E746- A750) , but not wild type EGFR of vertebrates.

Storage Conditions: Store at - 20°C. Avoid freeze / thaw cycles


Company Contact:


  • Phone: 6109452007

  • Address: 24 Whitewoods Lane, Malvern, PA, USA

  • Email: Email


Published date: May 4, 2016 -

  • Business Description: NewEast Biosciences are specialized in generating protein configuration specific monoclonal antibodies that recognize active (GTP bound) G proteins (including Ras superfamily small GTPases and heterotrimeric G proteins). These unique antibodies do not recognize the inactive (GDP bound) G proteins. These monoclonal antibodies have been successfully used to immunoprecipitate active G proteins from cell lysates, and for immunohistochemical staining of active G proteins in cultured cells or in tissue sections. Hence, these antibodies can be used to study the spatial and temporal dynamics of cellular signaling involving big and small G proteins, the future direction of signal transduction studies.

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