Synphase Lanterns A Modular Solid Phase Platform As An Alternative To Resin - Chinaprice: contact company for price
alternative to resins
Characteristics of Ideal Solid Phase
1. Equivalent Reactivity of Functional Groups
approach solution phase conditions
2. Physicochemical Compatibility
with compounds being synthesized
with polar and non- polar solvents
3. Good Mechanical Properties
under wide range of solvent, temperature and pressures
Why Solid Phase Synthesis?
1. Simplifies parallel handling
2. Readily automated
3. Drive reactions to completion with excess reagent
4. Remove excess: reagents and
5. by- products by washing
Morphology of Solid Supports
low cross- linked copolymers such as polystyrene ( PS) ,
polyamides ( PA) , etc.
Macroporous or macroreticular resins
controlled- pore glass or highly cross- linked polystyrene.
composed of two layers
mobile accessible surface on a solid core material
eg. glass, PTFE ( Polytetrafluoroethene) , PP( polypropylene) or
highly cross- linked PS
Launched March 2000
Adopted as library synthesis platform by several big
Polystyrene or Polyamide surface on polypropylene
Quantised solid phase
Can be used as Matrix Format or Direct sort format
Structure of Lantern Surface
Uniform 50 micron graft
( - 80& deg; C to 100& deg; C )
Stable to agitation
SynPhaseTM technology used in Parallel mode
Lanterns ( in white) fixed to stems ( in blue) which are fixed
to stem holder in 8x12 array format ( 96) . This can now go
into 96 well plate each having different reaction mixtures.
The Classic MultiPinTM Method
Convenient 8x12 array format
Ideal for washes and simultaneous cleavage
Any chemistry carried out on Resins is transferable to
Lanterns with minimum modification
Synthesis of peptide VQAAIDYING on Rink Lanterns using a CEM
DISCOVER MICROWAVE UNIT
Solution A 1.46 g HBTU in 10 mL DMF
Solution B 0.8 g HOBT in 10 mL DMF
AA Production solution 0.82 mL
Solution A 0.64 mL
Solution B 0.64 mL
NMM 0.064 mL
Fundamental differences between SynPhase& trade; Lanterns and
Rapid and uniform kinetics
solid phase synthesis
parallel synthesis, tagged based techniques
solution phase synthesis
scavengers, catch and release, support bound reagents
- Posted By: Beijing ZhogXingBoMai Co, Ltd.
- Phone: 8601082037209
- Address: Rm.1310 Tower A Huayuan Building No.32 Huayuan Eas, beijing, China
- Website: http://biomedi.com.cn
Published date: April 30, 2014 -
- Business Description: Beijing ZhogXingBoMai Co, Ltd. is a company ,which is specialized in
producing, processing and marketing peptide products, biological
laboratory equipment, healthcare equipment, microscopes and water
purification system .We have a complete and scientific quality
management system. The integrity, strength and product quality of
Beijing Zhongxing Technology Co, Ltd. is recognized by the industry.
Welcome to visit, guide and to negotiate business.
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