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Aprotinin Usp Bp Ip Ep Manufacturer - India

price: contact company for price

CERTIFICATE OF ANALYSIS

Product Name Aprotinin CAS No:

Batch No: APR/ 011114 A. R. No 14/ FP/ APR/ 0111

Date of Manufacture Nov- 2014 Date of Analysis 02- 11- 14

Batch Quantity 100 kg Date of Retest Jan- 2017

Sr. No Test Results Acceptance Criteria

1. Appearance Complies A white powder or Pallide- flavens powder

2. PH 6.0 5.0 to 7.0

3. Identification Complies Complies

4. Clarity of solution Complies Complies

5. Absorption 277 nm

0.7 Have the largest absorption at λ =277nm not more than 0.8

6. Water content 5.42%

NMT 6.0%

7. Protein of higher molecular mass 1.7% NMT 3.0%

8. Pyrogen Complies

Complies

9. Abnormal toxity Complies Complies

10. Depressor substance Complies Complies

11. Valeance 3.48EPU/ mg not less than 3.0EPU/ mg on dry basis

. .

protinin

Aprotinin. png

Systematic ( IUPAC) name

Aprotinin

Clinical data

AHFS/ Drugs. com monograph

Pregnancy

category

X

Legal status

UK: Prescription- only ( POM)

RX/ POM

Dependence

liability None

Routes of

administration Intravenous

Pharmacokinetic data

Bioavailability 100% ( intravenous)

Identifiers

CAS Registry Number 9087- 70- 1 Yes 9004- 04- 0

ATC code B02AB01

IUPHAR/ BPS 6570

DrugBank DB06692 Yes

UNII 04XPW8C0FL Yes

KEGG D02971 Yes

ChEMBL CHEMBL1201619

Synonyms Trasylol, bovine pancreatic trypsin inhibitor

Chemical data

Formula C284H432N84O79S7

Molecular mass 6511.51 g/ mol

( what is this? ) ( verify)

The drug aprotinin ( Trasylol, previously Bayer and now Nordic Group pharmaceuticals) , is the small protein bovine pancreatic trypsin inhibitor ( BPTI) , an antifibrinolytic molecule that inhibits trypsin and related proteolytic enzymes. Under the trade name Trasylol, aprotinin was used as a medication administered by injection to reduce bleeding during complex surgery, such as heart and liver surgery. Its main effect is the slowing down of fibrinolysis, the process that leads to the breakdown of blood clots. The aim in its use was to decrease the need for blood transfusions during surgery, as well as end- organ damage due to hypotension ( low blood pressure) as a result of marked blood loss. The drug was temporarily withdrawn worldwide in 2007 after studies suggested that its use increased the risk of complications or death; [ 1] this was confirmed by follow- up studies. Trasylol sales were suspended in May 2008, except for very restricted research use. In February 2012 the European Medicines Agency ( EMA) scientific committee reverted its previous standpoint regarding aprotinin, and has recommended that the suspension be lifted. [ 2] Nordic became distributor of aprotinin in 2012. [ 3]

Contents [ hide]

1 Chemistry

2 Mechanism of drug action

3 Drug efficacy

4 Drug safety

5 In vitro use

6 History

7 Current findings

8 References

9 External links

Chemistry[ edit]

BPTI seq ribbon sticks. jpg

BPTI sequence, with its folded 3D structure represented by a ribbon for the secondary structure and a stick model ( gray) for the backbone and sidechains.

Organism Bos taurus ( domestic cow)

Symbol PTI

Entrez 404172

PDB 4PTI More structures

RefSeq ( mRNA) NM_ 001001554

RefSeq ( Prot) NP_ 001001554

UniProt P00974


Company Contact:


  • Phone: 912406641875

  • Address: PLOT NO: 04 JALGAON ROAD, HARSOOL, AURANGABAD, India

  • Email: Email


Published date: September 5, 2015 -

  • Business Description: We, at SWAPNROOP, are committed to providing affordable Drugs &

    Pharmaceuticals of global quality standards to Pharma Companies all over

    the world. In our warehouse facilities, approved by FDA. we supply

    Pharmaceutical Finished products, Dental products and Active

    Pharmaceutical Ingredients.

    We, at SWAPNROOP, are committed to providing affordable Drugs & Pharmaceuticals of global quality standards to Pharma Companies all over the world. Our warehouse facilities is approved by FDA and we are specializes in sales and marketing of Pharmaceutical Finished products, Pharmaceutical Active Ingredients (API's) and Dental products, providing a wide range of quality and affordable products to a large number of pharmaceutical companies, reputed private and government/semi government organizations/ research centers as well as universities.

    We supply and market over 500 molecules and their combinations in multiple dosage forms, catering to patient needs in various therapies. These include Anti infectives, Cardiovascular, Pain management, Central Nervous System (CNS), Gastrointestinal, Respiratory, Dermatology, Orthopaedics, Nutritionals, Urology and Dental.

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