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  • Bexarotene Usp Ip Bp Ep Manufacturer - India

    price: contact company for price

    Bexarotene

    Bexarotene2DACS. svg

    Bexarotene3Dan. gif

    Systematic ( IUPAC) name

    4- [ 1- ( 5, 6, 7, 8- tetrahydro- 3, 5, 5, 8, 8- pentamethyl- 2- naphthalenyl) ethenyl] benzoic acid

    Clinical data

    Trade names Targretin

    AHFS/ Drugs. com monograph

    MedlinePlus a608006

    Licence data EMA: Link, US FDA: link

    Pregnancy

    category

    US: X ( Contraindicated)

    Legal status

    AU: Prescription Only ( S4)

    UK: Prescription- only ( POM)

    US: ℞ - only

    Routes of

    administration Oral and topical

    CERTIFICATE OF ANALYSIS

    Product Name Bexarotene CAS No: 153559- 49- 0

    Batch No: BEX/ 011114 A. R. No 14/ FP/ BEX/ 0111

    Date of Manufacture Nov- 2014 Date of Analysis 02- 11- 14

    Batch Quantity 100 kg Date of Retest Jan- 2017

    Sr. No Test Results Acceptance Criteria

    1. Appearance

    Complies

    White needle crystal

    2. Solubility Complies Soluble in DMSO, slightly soluble in ethanol

    3. Melting point 227ºC to 229ºC 225ºC to 230ºC

    4. Assay HPLC 99.3% NLT 99.0%

    5. Residue on ignition Complies NMT 0.1%

    6. Related substances

    Impurity A

    Impurity B

    Impurity C

    Impurity D

    0.33%

    0.27%

    Not detected

    0.09%

    NMT 0.5%

    NMT 0.15%

    7. Heavy metals Complies NMT 20 PPM

    8. Loss on drying 0.13% NMT 0.5%

    .

    Pharmacokinetic data

    Protein binding >99%

    Metabolism Hepatic ( CYP3A4- mediated)

    Biological half- life 7 hours

    Excretion Parent drug and metabolites are eliminated primarily through the hepatobiliary system. Less than 1% is excreted in the urine unchanged.

    Identifiers

    CAS Registry Number 153559- 49- 0 Yes

    ATC code L01XX25

    PubChem CID: 82146

    IUPHAR/ BPS 2807

    DrugBank DB00307 Yes

    ChemSpider 74139 Yes

    UNII A61RXM4375 Yes

    ChEBI CHEBI: 50859 Yes

    ChEMBL CHEMBL1023 Yes

    Chemical data

    Formula C24H28O2

    Molecular mass 348.478 g/ mol


    Company Contact:


    • Phone: 912406641875

    • Address: PLOT NO: 04 JALGAON ROAD, HARSOOL, AURANGABAD, India

    • Email: Email


    Published date: September 5, 2015 -

    • Business Description: We, at SWAPNROOP, are committed to providing affordable Drugs &

      Pharmaceuticals of global quality standards to Pharma Companies all over

      the world. In our warehouse facilities, approved by FDA. we supply

      Pharmaceutical Finished products, Dental products and Active

      Pharmaceutical Ingredients.

      We, at SWAPNROOP, are committed to providing affordable Drugs & Pharmaceuticals of global quality standards to Pharma Companies all over the world. Our warehouse facilities is approved by FDA and we are specializes in sales and marketing of Pharmaceutical Finished products, Pharmaceutical Active Ingredients (API's) and Dental products, providing a wide range of quality and affordable products to a large number of pharmaceutical companies, reputed private and government/semi government organizations/ research centers as well as universities.

      We supply and market over 500 molecules and their combinations in multiple dosage forms, catering to patient needs in various therapies. These include Anti infectives, Cardiovascular, Pain management, Central Nervous System (CNS), Gastrointestinal, Respiratory, Dermatology, Orthopaedics, Nutritionals, Urology and Dental.

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