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  • Bosutinib Usp Ip Bp Ep Manufacturer - India

    price: contact company for price

    Bosutinib

    Bosutinib2DACS. svg

    Bosutinib3Dan2. gif

    Systematic ( IUPAC) name

    4- [ ( 2, 4- dichloro- 5- methoxyphenyl) amino] - 6- methoxy- 7- [ 3- ( 4- methylpiperazin- 1- yl) propoxy] quinoline- 3- carbonitrile

    Clinical data

    Trade names Bosulif

    Licence data EMA: Link, US FDA: link

    Pregnancy

    category

    US: D ( Evidence of risk)

    Legal status

    UK: Prescription- only ( POM)

    US: ℞ - only

    Routes of

    administration Oral

    Pharmacokinetic data

    Protein binding 94–96%

    Metabolism By CYP3A4, to inactive metabolites

    Biological half- life 22.5±1.7 hours

    Excretion Foecal ( 91.3% ) and renal ( 3% )

    Identifiers

    CAS Registry Number 380843- 75- 4

    ATC code L01XE14

    PubChem CID: 5328940

    IUPHAR/ BPS 5710

    ChemSpider 4486102 Yes

    UNII 5018V4AEZ0 Yes

    ChEBI CHEBI: 39112 Yes

    ChEMBL CHEMBL288441 Yes

    Chemical data

    Formula C26H29Cl2N5O3

    Molecular mass 530.446 g/ mol

    SMILES

    Clc1c( OC) cc( c( Cl) c1) Nc4c( C# N) cnc3cc( OCCCN2CCN( CC2) C) c( OC) cc34

    InChI

    InChI=1S/ C26H29Cl2N5O3/ c1- 32- 6- 8- 33( 9- 7- 32) 5- 4- 10- 36- 25- 13- 21- 18( 11- 24( 25) 35- 3) 26( 17( 15- 29) 16- 30- 21) 31- 22- 14- 23( 34- 2) 20( 28) 12- 19( 22) 27/ h11- 14, 16H, 4- 10H2, 1- 3H3, ( H, 30, 31) Yes

    Key: UBPYILGKFZZVDX- UHFFFAOYSA- N Yes

    .

    CERTIFICATE OF ANALYSIS

    Product Name Bosutinib CAS No:

    Batch No: BOS/ 011114 A. R. No 14/ FP/ BOS/ 0111

    Date of Manufacture Nov- 2014 Date of Analysis 02- 11- 14

    Batch Quantity 100 kg Date of Retest Jan- 2017

    Sr. No Test Results Acceptance Criteria

    1. Appearance Complies White powder

    2. Melting point

    3. Residue on Ignition 0.03% NMT 0.1%

    4. Loss on drying 0.11% NMT 1.0%

    5. Heavy metals 20 PPM NMT 20 PPM

    6. Purity 99.79% NLT 99.0%


    Company Contact:


    • Phone: 912406641875

    • Address: PLOT NO: 04 JALGAON ROAD, HARSOOL, AURANGABAD, India

    • Email: Email


    Published date: September 5, 2015 -

    • Business Description: We, at SWAPNROOP, are committed to providing affordable Drugs &

      Pharmaceuticals of global quality standards to Pharma Companies all over

      the world. In our warehouse facilities, approved by FDA. we supply

      Pharmaceutical Finished products, Dental products and Active

      Pharmaceutical Ingredients.

      We, at SWAPNROOP, are committed to providing affordable Drugs & Pharmaceuticals of global quality standards to Pharma Companies all over the world. Our warehouse facilities is approved by FDA and we are specializes in sales and marketing of Pharmaceutical Finished products, Pharmaceutical Active Ingredients (API's) and Dental products, providing a wide range of quality and affordable products to a large number of pharmaceutical companies, reputed private and government/semi government organizations/ research centers as well as universities.

      We supply and market over 500 molecules and their combinations in multiple dosage forms, catering to patient needs in various therapies. These include Anti infectives, Cardiovascular, Pain management, Central Nervous System (CNS), Gastrointestinal, Respiratory, Dermatology, Orthopaedics, Nutritionals, Urology and Dental.

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