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Bupropion Hydrochloride Usp Ip Bp Ep Manufacturer - India

price: contact company for price

CERTIFICATE OF ANALYSIS

Product Name Bupropion hydrochloride CAS No: 31677- 93- 7

Batch No: BUP/ 011114 A. R. No 14/ FP/ BUP/ 0111

Date of Manufacture Nov- 2014 Date of Analysis 02- 11- 14

Batch Quantity 100 kg Date of Retest Jan- 2017

Sr. No Test Results Acceptance Criteria

1. Appearance Complies White powder

2. Identification Complies

Complies

Complies A. Infrared absorption

B. The retention time

C. Chloride test

3. Residue on ignition 0.08% NMT 0.1%

4. Melting point 234℃ 233ºC to 234℃

5. Water 0.40% NMT 0.5%

6. Assay 99.0% 98.0% to 102.0%

.

Bupropion

Skeletal formula of bupropion

Ball- and- stick model of the ( S) isomer of the bupropion molecule

Systematic ( IUPAC) name

( ±) - 2- ( tert- Butylamino) - 1- ( 3- chlorophenyl) propan- 1- one

Clinical data

Pronunciation / bjuː ˈ proʊ pi. ɒ n/ bew- proh- pee- on

Trade names Wellbutrin, Elontril, Zyban

AHFS/ Drugs. com monograph

MedlinePlus a695033

Licence data US FDA: link

Pregnancy

category

AU: B2

US: C ( Risk not ruled out)

Legal status

AU: Prescription Only ( S4)

CA: ℞ - only

UK: Prescription- only ( POM)

US: ℞ - only

Addiction

liability none to very low

Routes of

administration Medical: oral

Recreational: intranasal, intravenous

Pharmacokinetic data

Protein binding 84% ( bupropion) , 77% ( hydroxybupropion metabolite) , 42% ( threohydrobupropion metabolite) [ 1]

Metabolism Hepatic ( mostly CYP2B6- mediated hydroxylation, but with some contributions from CYP1A2, CYP2A6, CYP2C9, CYP3A4, CYP2E1 and CYP2C19) [ 1] [ 2] [ 3] [ 4]

Biological half- life 11 hours ( short- term dosing; parent compound) [ 5] 14–21 hours ( chronic dosing; parent compound – depends on formulation) , [ 1] [ 3] [ 6] 20 hours ( hydroxybupropion) , 33 hours ( erythrohydrobupropion) , 37 hours ( threohydrobupropion) [ 1] [ 3] [ 6] [ 7]

Excretion Renal ( 87% ; 0.5% unchanged) , Faecal ( 10% ) [ 2] [ 3] [ 6]

Identifiers

CAS Registry Number 34841- 39- 9 Yes

ATC code N06AX12

PubChem CID: 444

IUPHAR/ BPS 7135

DrugBank DB01156 Yes

ChemSpider 431 Yes

UNII 01ZG3TPX31 Yes

KEGG D07591 Yes

ChEBI CHEBI: 3219 Yes

ChEMBL CHEMBL894 Yes

Synonyms 3- Chloro- N- tert- butyl- β - keto- α - methylphenethylamine;

3- Chloro- N- tert- butylcathinone

Chemical data

Formula C13H18ClNO

Molecular mass 239.74 g/ mol


Company Contact:


  • Phone: 912406641875

  • Address: PLOT NO: 04 JALGAON ROAD, HARSOOL, AURANGABAD, India

  • Email: Email


Published date: September 5, 2015 -

  • Business Description: We, at SWAPNROOP, are committed to providing affordable Drugs &

    Pharmaceuticals of global quality standards to Pharma Companies all over

    the world. In our warehouse facilities, approved by FDA. we supply

    Pharmaceutical Finished products, Dental products and Active

    Pharmaceutical Ingredients.

    We, at SWAPNROOP, are committed to providing affordable Drugs & Pharmaceuticals of global quality standards to Pharma Companies all over the world. Our warehouse facilities is approved by FDA and we are specializes in sales and marketing of Pharmaceutical Finished products, Pharmaceutical Active Ingredients (API's) and Dental products, providing a wide range of quality and affordable products to a large number of pharmaceutical companies, reputed private and government/semi government organizations/ research centers as well as universities.

    We supply and market over 500 molecules and their combinations in multiple dosage forms, catering to patient needs in various therapies. These include Anti infectives, Cardiovascular, Pain management, Central Nervous System (CNS), Gastrointestinal, Respiratory, Dermatology, Orthopaedics, Nutritionals, Urology and Dental.

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