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  • Bupropion Hydrochloride Usp Ip Bp Ep Manufacturer - India

    price: contact company for price

    CERTIFICATE OF ANALYSIS

    Product Name Bupropion hydrochloride CAS No: 31677- 93- 7

    Batch No: BUP/ 011114 A. R. No 14/ FP/ BUP/ 0111

    Date of Manufacture Nov- 2014 Date of Analysis 02- 11- 14

    Batch Quantity 100 kg Date of Retest Jan- 2017

    Sr. No Test Results Acceptance Criteria

    1. Appearance Complies White powder

    2. Identification Complies

    Complies

    Complies A. Infrared absorption

    B. The retention time

    C. Chloride test

    3. Residue on ignition 0.08% NMT 0.1%

    4. Melting point 234℃ 233ºC to 234℃

    5. Water 0.40% NMT 0.5%

    6. Assay 99.0% 98.0% to 102.0%

    .

    Bupropion

    Skeletal formula of bupropion

    Ball- and- stick model of the ( S) isomer of the bupropion molecule

    Systematic ( IUPAC) name

    ( ±) - 2- ( tert- Butylamino) - 1- ( 3- chlorophenyl) propan- 1- one

    Clinical data

    Pronunciation / bjuː ˈ proʊ pi. ɒ n/ bew- proh- pee- on

    Trade names Wellbutrin, Elontril, Zyban

    AHFS/ Drugs. com monograph

    MedlinePlus a695033

    Licence data US FDA: link

    Pregnancy

    category

    AU: B2

    US: C ( Risk not ruled out)

    Legal status

    AU: Prescription Only ( S4)

    CA: ℞ - only

    UK: Prescription- only ( POM)

    US: ℞ - only

    Addiction

    liability none to very low

    Routes of

    administration Medical: oral

    Recreational: intranasal, intravenous

    Pharmacokinetic data

    Protein binding 84% ( bupropion) , 77% ( hydroxybupropion metabolite) , 42% ( threohydrobupropion metabolite) [ 1]

    Metabolism Hepatic ( mostly CYP2B6- mediated hydroxylation, but with some contributions from CYP1A2, CYP2A6, CYP2C9, CYP3A4, CYP2E1 and CYP2C19) [ 1] [ 2] [ 3] [ 4]

    Biological half- life 11 hours ( short- term dosing; parent compound) [ 5] 14–21 hours ( chronic dosing; parent compound – depends on formulation) , [ 1] [ 3] [ 6] 20 hours ( hydroxybupropion) , 33 hours ( erythrohydrobupropion) , 37 hours ( threohydrobupropion) [ 1] [ 3] [ 6] [ 7]

    Excretion Renal ( 87% ; 0.5% unchanged) , Faecal ( 10% ) [ 2] [ 3] [ 6]

    Identifiers

    CAS Registry Number 34841- 39- 9 Yes

    ATC code N06AX12

    PubChem CID: 444

    IUPHAR/ BPS 7135

    DrugBank DB01156 Yes

    ChemSpider 431 Yes

    UNII 01ZG3TPX31 Yes

    KEGG D07591 Yes

    ChEBI CHEBI: 3219 Yes

    ChEMBL CHEMBL894 Yes

    Synonyms 3- Chloro- N- tert- butyl- β - keto- α - methylphenethylamine;

    3- Chloro- N- tert- butylcathinone

    Chemical data

    Formula C13H18ClNO

    Molecular mass 239.74 g/ mol


    Company Contact:


    • Phone: 912406641875

    • Address: PLOT NO: 04 JALGAON ROAD, HARSOOL, AURANGABAD, India

    • Email: Email


    Published date: September 5, 2015 -

    • Business Description: We, at SWAPNROOP, are committed to providing affordable Drugs &

      Pharmaceuticals of global quality standards to Pharma Companies all over

      the world. In our warehouse facilities, approved by FDA. we supply

      Pharmaceutical Finished products, Dental products and Active

      Pharmaceutical Ingredients.

      We, at SWAPNROOP, are committed to providing affordable Drugs & Pharmaceuticals of global quality standards to Pharma Companies all over the world. Our warehouse facilities is approved by FDA and we are specializes in sales and marketing of Pharmaceutical Finished products, Pharmaceutical Active Ingredients (API's) and Dental products, providing a wide range of quality and affordable products to a large number of pharmaceutical companies, reputed private and government/semi government organizations/ research centers as well as universities.

      We supply and market over 500 molecules and their combinations in multiple dosage forms, catering to patient needs in various therapies. These include Anti infectives, Cardiovascular, Pain management, Central Nervous System (CNS), Gastrointestinal, Respiratory, Dermatology, Orthopaedics, Nutritionals, Urology and Dental.

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