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Loxapine Succinate Usp Ip Bp Ep Manufacturer - India

price: contact company for price

CERTIFICATE OF ANALYSIS

Product Name Loxapine Succinate USP CAS No: 27833- 64- 3

Batch No: LOX/ 030313 A. R. No 13/ FP/ LIOX/ 0303

Date of Manufacture Feb- 2013 Date of Analysis 02- 02- 13

Batch Quantity 165 kg Date of Retest Jan- 2016

Sr. No Test Results Acceptance Criteria

1. Appearance

2. Solubility

3. Identification

Complies By IR Spectrum: The infrared absorption spectrum of the test sample exhibits maxima only at the same wavelengths as that of the working standard.

4. Loss on drying 0.23% NMT 0.5%

5. Heavy Metals Complies 20ppm

6. Residue On Ignition 0.053% NMT 0.1%

7. Assay HPLC 99.56% 98.5% –101.0%

8. Melting Temperature 151º 150°–153°

. .

Loxapine

Loxapine2DACS. svg

Loxapine46. jpg

Systematic ( IUPAC) name

2- Chloro- 11- ( 4- methylpiperazin- 1- yl) dibenzo[ b, f] [ 1, 4] oxazepine

Clinical data

Trade names Loxapac, Loxitane, Adasuve

AHFS/ Drugs. com monograph

MedlinePlus a682311

Licence data EMA: Link, US Daily Med: link

Pregnancy

category

US: C ( Risk not ruled out)

Legal status

AU: Prescription Only ( S4)

US: ℞ - only

Routes of

administration Inhalation, oral

Pharmacokinetic data

Protein binding 96.8% [ 1]

Metabolism Liver, extensive; active metabolites include amoxapine and 8- hydroxyloxapine. Inhibits P- glycoprotein and is a substrate of CYP1A2, CYP3A4 and CYP2D6[ 1]

Biological half- life Oral, 4 hours; Inhalation, 7.61 hours [ 1]

Excretion Majority are excreted within 24 hours. Main route through urine( conjugated metabolites) ; Small amounts through the faeces( unconjugated metabolites)

Identifiers

CAS Registry Number 1977- 10- 2 Yes

ATC code N05AH01

PubChem CID: 3964

IUPHAR/ BPS 205

DrugBank DB00408

ChemSpider 3827 Yes

UNII LER583670J Yes

KEGG D02340 Yes

ChEBI CHEBI: 50841

ChEMBL CHEMBL831 Yes

Chemical data

Formula C18H18ClN3O

Molecular mass 327.808 g/ mol

SMILES[ show]

InChI[ show]

Physical data

Melting point 109 to 110 °C ( 228 to 230 °F)


Company Contact:


  • Phone: 912406641875

  • Address: PLOT NO: 04 JALGAON ROAD, HARSOOL, AURANGABAD, India

  • Email: Email


Published date: September 9, 2015 -

  • Business Description: We, at SWAPNROOP, are committed to providing affordable Drugs &

    Pharmaceuticals of global quality standards to Pharma Companies all over

    the world. In our warehouse facilities, approved by FDA. we supply

    Pharmaceutical Finished products, Dental products and Active

    Pharmaceutical Ingredients.

    We, at SWAPNROOP, are committed to providing affordable Drugs & Pharmaceuticals of global quality standards to Pharma Companies all over the world. Our warehouse facilities is approved by FDA and we are specializes in sales and marketing of Pharmaceutical Finished products, Pharmaceutical Active Ingredients (API's) and Dental products, providing a wide range of quality and affordable products to a large number of pharmaceutical companies, reputed private and government/semi government organizations/ research centers as well as universities.

    We supply and market over 500 molecules and their combinations in multiple dosage forms, catering to patient needs in various therapies. These include Anti infectives, Cardiovascular, Pain management, Central Nervous System (CNS), Gastrointestinal, Respiratory, Dermatology, Orthopaedics, Nutritionals, Urology and Dental.

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