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  • Loxapine Succinate Usp Ip Bp Ep Manufacturer - India

    price: contact company for price

    CERTIFICATE OF ANALYSIS

    Product Name Loxapine Succinate USP CAS No: 27833- 64- 3

    Batch No: LOX/ 030313 A. R. No 13/ FP/ LIOX/ 0303

    Date of Manufacture Feb- 2013 Date of Analysis 02- 02- 13

    Batch Quantity 165 kg Date of Retest Jan- 2016

    Sr. No Test Results Acceptance Criteria

    1. Appearance

    2. Solubility

    3. Identification

    Complies By IR Spectrum: The infrared absorption spectrum of the test sample exhibits maxima only at the same wavelengths as that of the working standard.

    4. Loss on drying 0.23% NMT 0.5%

    5. Heavy Metals Complies 20ppm

    6. Residue On Ignition 0.053% NMT 0.1%

    7. Assay HPLC 99.56% 98.5% –101.0%

    8. Melting Temperature 151º 150°–153°

    . .

    Loxapine

    Loxapine2DACS. svg

    Loxapine46. jpg

    Systematic ( IUPAC) name

    2- Chloro- 11- ( 4- methylpiperazin- 1- yl) dibenzo[ b, f] [ 1, 4] oxazepine

    Clinical data

    Trade names Loxapac, Loxitane, Adasuve

    AHFS/ Drugs. com monograph

    MedlinePlus a682311

    Licence data EMA: Link, US Daily Med: link

    Pregnancy

    category

    US: C ( Risk not ruled out)

    Legal status

    AU: Prescription Only ( S4)

    US: ℞ - only

    Routes of

    administration Inhalation, oral

    Pharmacokinetic data

    Protein binding 96.8% [ 1]

    Metabolism Liver, extensive; active metabolites include amoxapine and 8- hydroxyloxapine. Inhibits P- glycoprotein and is a substrate of CYP1A2, CYP3A4 and CYP2D6[ 1]

    Biological half- life Oral, 4 hours; Inhalation, 7.61 hours [ 1]

    Excretion Majority are excreted within 24 hours. Main route through urine( conjugated metabolites) ; Small amounts through the faeces( unconjugated metabolites)

    Identifiers

    CAS Registry Number 1977- 10- 2 Yes

    ATC code N05AH01

    PubChem CID: 3964

    IUPHAR/ BPS 205

    DrugBank DB00408

    ChemSpider 3827 Yes

    UNII LER583670J Yes

    KEGG D02340 Yes

    ChEBI CHEBI: 50841

    ChEMBL CHEMBL831 Yes

    Chemical data

    Formula C18H18ClN3O

    Molecular mass 327.808 g/ mol

    SMILES[ show]

    InChI[ show]

    Physical data

    Melting point 109 to 110 °C ( 228 to 230 °F)


    Company Contact:


    • Phone: 912406641875

    • Address: PLOT NO: 04 JALGAON ROAD, HARSOOL, AURANGABAD, India

    • Email: Email


    Published date: September 9, 2015 -

    • Business Description: We, at SWAPNROOP, are committed to providing affordable Drugs &

      Pharmaceuticals of global quality standards to Pharma Companies all over

      the world. In our warehouse facilities, approved by FDA. we supply

      Pharmaceutical Finished products, Dental products and Active

      Pharmaceutical Ingredients.

      We, at SWAPNROOP, are committed to providing affordable Drugs & Pharmaceuticals of global quality standards to Pharma Companies all over the world. Our warehouse facilities is approved by FDA and we are specializes in sales and marketing of Pharmaceutical Finished products, Pharmaceutical Active Ingredients (API's) and Dental products, providing a wide range of quality and affordable products to a large number of pharmaceutical companies, reputed private and government/semi government organizations/ research centers as well as universities.

      We supply and market over 500 molecules and their combinations in multiple dosage forms, catering to patient needs in various therapies. These include Anti infectives, Cardiovascular, Pain management, Central Nervous System (CNS), Gastrointestinal, Respiratory, Dermatology, Orthopaedics, Nutritionals, Urology and Dental.

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