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  • Methenamine Usp Ip Bp Ep Manufacturer - India

    price: contact company for price

    CERTIFICATE OF ANALYSIS

    Product Name Methenamine, USP CAS No: 100- 97- 0

    Batch No: MET/ 030313 A. R. No 13/ FP/ MET/ 0303

    Date of Manufacture Feb- 2013 Date of Analysis 02- 02- 13

    Batch Quantity 165 kg Date of Retest Jan- 2016

    Sr. No Test Results Acceptance Criteria

    1. Appearance

    2. Solubility

    3. Identification

    Complies By IR Spectrum: The infrared absorption spectrum of the test sample exhibits maxima only at the same wavelengths as that of the working standard.

    4. Loss on drying 1.1% NMT 2.0%

    5. Heavy Metals Complies 10ppm

    6. Residue On Ignition 0.065% NMT 0.1%

    7. Assay HPLC 99.78% 99.0% –100.5%

    Hexamethylenetetramine

    Hexamine. svg

    Hexamine- 3D- balls. png

    Names

    IUPAC name

    1, 3, 5, 7- Tetraazatricyclo[ ] decane

    Other names

    Hexamine; Methenamine;

    Urotropine; 1, 3, 5, 7- tetraazaadamantane, Formin, Aminoform

    Identifiers

    CAS Registry Number

    100- 97- 0 Yes

    ATC code J01XX05

    ChEBI CHEBI: 6824 Yes

    ChEMBL ChEMBL1201270

    ChemSpider 3959 Yes

    EC number 202- 905- 8

    InChI[ show]

    Jmol- 3D images Image

    KEGG D00393 Yes

    MeSH Methenamine

    PubChem 4101

    SMILES[ show]

    UNII J50OIX95QV Yes

    Properties

    Chemical formula

    C6H12N4

    Molar mass 140.186 g/ mol

    Appearance White crystalline solid

    Density 1.33 g/ cm3 ( at 20 °C)

    Melting point 280 °C ( 536 °F; 553 K) ( sublimes)

    Solubility in water

    85.3 g/ 100 mL

    Acidity ( pKa) 4.89[ 1]

    Hazards

    Main hazards Highly flammable, harmful

    Flash point 250 °C ( 482 °F; 523 K)

    Autoignition

    temperature

    410 °C ( 770 °F; 683 K)

    Except where otherwise noted, data are given for materials in their standard state ( at 25 °C [ 77 °F] , 100 kPa) .

    Chemical Compound

    Hexamethylenetetramine or methenamine is a heterocyclic organic compound with the formula ( CH2) 6N4. This white crystalline compound is highly soluble in water and polar organic solvents. It has a cage- like structure similar to adamantane. Wikipedia

    Formula: C6H12N4

    Molar mass: 140.186 g/ mol

    IUPAC ID: 1, 3, 5, 7- Tetraazatricyclo[ ] decane

    Density: 1.33 g/ cm³

    Boiling point: 280 °C

    Soluble in: Water

    Hexamethylenetetramine or methenamine is a heterocyclic organic compound with the formula ( CH2) 6N4. This white crystalline compound is highly soluble in water and polar organic solvents. It has a cage- like structure similar to adamantane. It is useful in the synthesis of other chemical compounds, e. g. plastics, pharmaceuticals, rubber additives. It sublimes in a vacuum at 280 °C.

    Hexamethylenetetramine is prepared industrially by combining formaldehyde and ammonia. The reaction can be conducted in gas- phase and in solution.

    The molecule has a symmetric tetrahedral cage- like structure, similar to adamantane, whose four ' corners' are nitrogen atoms and ' edges' are methylene bridges. Although the molecular shape defines a cage, no void space is available at the interior for binding other atoms or molecules, unlike crown ethers or larger cryptand structures.

    The molecule behaves like an amine base, undergoing protonation and N- alkylation.

    When treated with nitric acid, hexamine forms the explosive RDX ( known chemically as cyclotrimethylenetrinitramine) . Hexamine reacts with hydrogen peroxide to form hexamethylene triperoxide diamine or dilute sulfuric acid.

    The dominant use of hexamethylenetetramine is in the production of powdery or liquid preparations of phenolic resins and phenolic resin moulding compounds, where it is added as a hardening component. These products are used as binders, e. g. in brake and clutch linings, abrasive products, non- woven textiles, formed parts produced by moulding processes, and fireproof materials.

    As the mandelic acid salt ( generic methenamine mandelate, USP) it is used for the treatment of urinary tract infection. It decomposes at an acidic pH to form formaldehyde and ammonia, and the formaldehyde is bactericidal; the mandelic acid adds to this effect. Urinary acidity is typically ensured by co- administering vitamin C ( ascorbic acid) or ammonium chloride. Its use had temporarily been reduced in the late 1990s, due to adverse effects, particularly chemically- induced hemorrhagic cystitis in overdose, but its use has now been re- approved because of the prevalence of antibiotic resistance to more commonly used drugs. This drug is particularly suitable for long- term prophylactic treatment of urinary tract infection, because bacteria do not develop resistance to formaldehyde. It should not be used in the presence of renal insufficiency.


    Company Contact:


    • Phone: 912406641875

    • Address: PLOT NO: 04 JALGAON ROAD, HARSOOL, AURANGABAD, India

    • Email: Email


    Published date: September 10, 2015 -

    • Business Description: We, at SWAPNROOP, are committed to providing affordable Drugs &

      Pharmaceuticals of global quality standards to Pharma Companies all over

      the world. In our warehouse facilities, approved by FDA. we supply

      Pharmaceutical Finished products, Dental products and Active

      Pharmaceutical Ingredients.

      We, at SWAPNROOP, are committed to providing affordable Drugs & Pharmaceuticals of global quality standards to Pharma Companies all over the world. Our warehouse facilities is approved by FDA and we are specializes in sales and marketing of Pharmaceutical Finished products, Pharmaceutical Active Ingredients (API's) and Dental products, providing a wide range of quality and affordable products to a large number of pharmaceutical companies, reputed private and government/semi government organizations/ research centers as well as universities.

      We supply and market over 500 molecules and their combinations in multiple dosage forms, catering to patient needs in various therapies. These include Anti infectives, Cardiovascular, Pain management, Central Nervous System (CNS), Gastrointestinal, Respiratory, Dermatology, Orthopaedics, Nutritionals, Urology and Dental.

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