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  • Vincristine Sulphate Ip Bp Ep Manufacturer - India

    price: contact company for price

    CERTIFICATE OF ANALYSIS

    Product Name Vincristine Sulphate CAS No: 42971- 09- 5

    Batch No: VIN/ 011114 A. R. No 14/ FP/ VIN/ 0111

    Date of Manufacture Nov- 2014 Date of Analysis 02- 11- 14

    Batch Quantity 100 kg Date of Retest Jan- 2017

    Sr. No Test Results Acceptance Criteria

    1. Appearance Complies White or slightly yellowish crystalline powder very hygroscopic

    2. Identification Complies Positive

    3. COLOUR & CLARIFICATION Complies Clear and not more intensely coloured than the reference solutions

    4. SOLUBILITY Complies Soluble in water

    5. PH 4.0 3.5 to 4.5

    6. RELATED COMPOUNDS

    Individual

    Total

    0.81%

    1.36%

    NMT 1.0%

    NMT 4.0%

    7. ENDOTOXIN 0.25EU/ mg NMT 0.33 EU/ mg

    8. Assay 98.64% 95.0% to 105.0%

    9. RESIDUAL SOLVENTS

    Ethanol

    Methanol

    Chloroform

    0.4%

    0.2%

    0.004%

    NMT 0.5%

    NMT 0.3%

    NMT 0.006%

    10. Loss on drying 2.6% NMT 3.0%

    Vincristine. svg

    Vincristine3DanBS. gif

    Systematic ( IUPAC) name

    ( 3aR, 3a1R, 4R, 5S, 5aR, 10bR) - Methyl 4- acetoxy- 3a- ethyl- 9- ( ( 5S, 7S, 9S) - 5- ethyl- 5- hydroxy- 9- ( methoxycarbonyl) - 2, 4, 5, 6, 7, 8, 9, 10- octahydro- 1H- 3, 7- methano[ 1] azacycloundecino[ 5, 4- b] indol- 9- yl) - 6- formyl- 5- hydroxy- 8- methoxy- 3a, 3a1, 4, 5, 5a, 6, 11, 12- octahydro- 1H- indolizino[ 8, 1- cd] carbazole- 5- carboxylate

    Clinical data

    Trade names Oncovin

    AHFS/ Drugs. com monograph

    MedlinePlus a682822

    Pregnancy

    category

    AU: D

    US: D ( Evidence of risk)

    Legal status

    AU: Prescription Only ( S4)

    CA: ℞ - only

    UK: Prescription- only ( POM)

    US: ℞ - only

    Routes of

    administration intravenous

    Pharmacokinetic data

    Bioavailability n/ a ( not reliably absorbed by the GI tract) [ 1]

    Protein binding ~44% [ 2]

    Metabolism Liver, mostly via CYP3A4 and CYP3A5[ 1]

    Biological half- life 19 to 155 hours ( mean: 85 hours) [ 1]

    Excretion Faeces ( 70- 80% ) , urine ( 10- 20% ) [ 1]

    Identifiers

    CAS Registry Number 57- 22- 7 Yes

    ATC code L01CA02

    PubChem CID: 5978

    IUPHAR/ BPS 6785

    DrugBank DB00541 Yes

    ChemSpider 5758 Yes

    UNII 5J49Q6B70F Yes

    KEGG D08679 Yes

    ChEBI CHEBI: 28445 Yes

    ChEMBL CHEMBL303560

    Chemical data

    Formula C46H56N4O10

    Molecular mass 824.958 g/ mol


    Company Contact:


    • Phone: 912406641875

    • Address: PLOT NO: 04 JALGAON ROAD, HARSOOL, AURANGABAD, India

    • Email: Email


    Published date: September 14, 2015 -

    • Business Description: We, at SWAPNROOP, are committed to providing affordable Drugs &

      Pharmaceuticals of global quality standards to Pharma Companies all over

      the world. In our warehouse facilities, approved by FDA. we supply

      Pharmaceutical Finished products, Dental products and Active

      Pharmaceutical Ingredients.

      We, at SWAPNROOP, are committed to providing affordable Drugs & Pharmaceuticals of global quality standards to Pharma Companies all over the world. Our warehouse facilities is approved by FDA and we are specializes in sales and marketing of Pharmaceutical Finished products, Pharmaceutical Active Ingredients (API's) and Dental products, providing a wide range of quality and affordable products to a large number of pharmaceutical companies, reputed private and government/semi government organizations/ research centers as well as universities.

      We supply and market over 500 molecules and their combinations in multiple dosage forms, catering to patient needs in various therapies. These include Anti infectives, Cardiovascular, Pain management, Central Nervous System (CNS), Gastrointestinal, Respiratory, Dermatology, Orthopaedics, Nutritionals, Urology and Dental.

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