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  • Forsythia Suspensa Thumb Vahl Phillyrin Cas No 487 41 2 - China

    price: contact company for price

    Phillyrin, an active constituent found in many medicinal plants and

    certain functional foods, has anti- obesity activity in vivo. The aim of

    our study was to provide new data on the molecular mechanism( s)

    underlying the role of Phillyrin in the prevention of high glucose-

    induced lipid accumulation in human HepG2 hepatocytes. We found that

    Phillyrin suppressed high glucose- induced lipid accumulation in HepG2

    cells. Phillyrin strongly inhibited high glucose- induced fatty acid

    synthase ( FAS) expression by modulating sterol regulatory element-

    binding protein- 1c ( SREBP- 1c) activation. Moreover, use of the

    pharmacological AMP- activated protein kinase ( AMPK) inhibitor compound

    C revealed that AMPK is essential for suppressing SREBP- 1c expression

    in Phillyrin- treated cells. Finally, we found that liver kinase B1 (

    LKB1) phosphorylation is required for the Phillyrin- enhanced activation

    of AMPK in HepG2 hepatocytes. These results indicate that Phillyrin

    prevents lipid accumulation in HepG2 cells by blocking the expression of

    SREBP- 1c and FAS through LKB1/ AMPK activation, suggesting that

    Phillyrin is a novel AMPK activator with a role in the prevention and

    treatment of obesity.

    Herbal Extract

    • Variety: Forsythia Suspensa ( Thumb) Vahl Extract

    • Form: Powder

    • Part: fruit

    • Extraction Type: Solvent Extraction

    • Packaging: Drum

    • Place of Origin: Sichuan, China ( Mainland)

    • Grade: Food& Pharmaceutical Grade

    • Model Number: 100% Nature

    • Appearance: brown Yellow Powder

    • Assay: HPLC

    • CAS No: 487- 41- 2

    1. Phillyrin has anti- obesity effect in nutritive obesity mice.

    2. Phillyrin attenuates tumor necrosis factor α- mediated insulin resistance and lipolytic acceleration in 3T3- L1 adipocytes.

    3. Phillyrin prevents lipid accumulation in HepG2 cells by blocking the expression of SREBP- 1c and FAS through LKB1/ AMPK activation, so it is a novel AMPK activator with a role in the prevention and treatment of obesity


    Company Contact:


    • Phone: 8618280535753

    • Address: guangming road, Deyang, China

    • Email: Email

    Published date: March 23, 2016 -

    • Business Description: Sichuan Sinovoa Biologicals Co., Ltd. founded in 2002, is a modern

      enterprise integrating of natural active component

      extraction、R&D、production and marketing. Now our main products

      are: Berberine Hydochloride,Baicalin,Oleanolic acid, Rutin,

      Hesperidin, Chlorogenic acid, Fructus Forsythiae, Andrographolide,

      Astragalus Polysaccharide, Berberine Sulfate and so on. Berberine

      Hydrochlorie is the star product with purity 97% available or

      following customer s standard.

      Our factory is located in ShiFang Industrial Development Zone, and lies in the raw material supplying base, so Sinovoa has its unique location advantage. After more than 10 years growth, now it has mature OHSMS、advanced processing & testing equipment、scientific & effective innovation system and a group of professional talented people. All these factors ensure Sinovoa supplying steady quality products to meet market s demand in the maximum.

      Sinovoa follows strictly the concept Quality uppermost、 Customer first、Credit Premier、Non-stop innovation and its eternal mission is providing customers the best product. With offering quality products and reasonable price, Sinovoa is ready to serve all customers as before in future. All staff here sincerely send thanks to customers from home and abroad for their supports on us and let us move on together for further development and mutual benefit.

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