Forsythia Suspensa Thumb Vahl Phillyrin Cas No 487 41 2 - Chinaprice: contact company for price
certain functional foods, has anti- obesity activity in vivo. The aim of
our study was to provide new data on the molecular mechanism( s)
underlying the role of Phillyrin in the prevention of high glucose-
induced lipid accumulation in human HepG2 hepatocytes. We found that
Phillyrin suppressed high glucose- induced lipid accumulation in HepG2
cells. Phillyrin strongly inhibited high glucose- induced fatty acid
synthase ( FAS) expression by modulating sterol regulatory element-
binding protein- 1c ( SREBP- 1c) activation. Moreover, use of the
pharmacological AMP- activated protein kinase ( AMPK) inhibitor compound
C revealed that AMPK is essential for suppressing SREBP- 1c expression
in Phillyrin- treated cells. Finally, we found that liver kinase B1 (
LKB1) phosphorylation is required for the Phillyrin- enhanced activation
of AMPK in HepG2 hepatocytes. These results indicate that Phillyrin
prevents lipid accumulation in HepG2 cells by blocking the expression of
SREBP- 1c and FAS through LKB1/ AMPK activation, suggesting that
Phillyrin is a novel AMPK activator with a role in the prevention and
treatment of obesity.
â€¢ Variety: Forsythia Suspensa ( Thumb) Vahl Extract
â€¢ Form: Powder
â€¢ Part: fruit
â€¢ Extraction Type: Solvent Extraction
â€¢ Packaging: Drum
â€¢ Place of Origin: Sichuan, China ( Mainland)
â€¢ Grade: Food& Pharmaceutical Grade
â€¢ Model Number: 100% Nature
â€¢ Appearance: brown Yellow Powder
â€¢ Assay: HPLC
â€¢ CAS No: 487- 41- 2
1. Phillyrin has anti- obesity effect in nutritive obesity mice.
2. Phillyrin attenuates tumor necrosis factor Î±- mediated insulin resistance and lipolytic acceleration in 3T3- L1 adipocytes.
3. Phillyrin prevents lipid accumulation in HepG2 cells by blocking the expression of SREBP- 1c and FAS through LKB1/ AMPK activation, so it is a novel AMPK activator with a role in the prevention and treatment of obesity
- Posted By: Sichuan Sinovoa Biologicals Co.,Ltd
- Phone: 8618280535753
- Address: guangming road, Deyang, China
Published date: March 23, 2016 -
- Business Description: Sichuan Sinovoa Biologicals Co., Ltd. founded in 2002, is a modern
enterprise integrating of natural active component
extractionã€R&Dã€production and marketing. Now our main products
are: Berberine Hydochloride,Baicalin,Oleanolic acid, Rutin,
Hesperidin, Chlorogenic acid, Fructus Forsythiae, Andrographolide,
Astragalus Polysaccharide, Berberine Sulfate and so on. Berberine
Hydrochlorie is the star product with purity 97% available or
following customer s standard.
Our factory is located in ShiFang Industrial Development Zone, and lies in the raw material supplying base, so Sinovoa has its unique location advantage. After more than 10 years growth, now it has mature OHSMSã€advanced processing & testing equipmentã€scientific & effective innovation system and a group of professional talented people. All these factors ensure Sinovoa supplying steady quality products to meet market s demand in the maximum.
Sinovoa follows strictly the concept Quality uppermostã€ Customer firstã€Credit Premierã€Non-stop innovation and its eternal mission is providing customers the best product. With offering quality products and reasonable price, Sinovoa is ready to serve all customers as before in future. All staff here sincerely send thanks to customers from home and abroad for their supports on us and let us move on together for further development and mutual benefit.
Pharmaceuticals Raw MaterialsPharmaceuticals - Raw Materials - Sichuan Sinovoa Biologicals Co.,Ltd - China - March 23, 2016 - contact company for price
Sichuan Sinovoa Biologicals Co. , Ltd. founded in 2002, is a modern enterprise integrating of natural active component extractionã€R& Dã€production and marketing. Now our main products are: Berberine Hydochloride, Baicalin, Oleanolic acid, Rutin, H...
Berberine HydrochloridePharmaceuticals - Raw Materials - Sichuan Sinovoa Biologicals Co.,Ltd - China - March 23, 2016 - contact company for price
Berberine Hydrochloride is an alkaloid derived from Chinese goldthread, bark of cork tree and other plants. It can be also synthesized in artificial method. It is used as raw material to make preparations, which are usually administered the treatment...
Scutellria Baicalensis ExtractPharmaceuticals - Raw Materials - Sichuan Sinovoa Biologicals Co.,Ltd - China - March 23, 2016 - contact company for price
Baicalin is found in several species in the genus Scutellaria, including Scutellaria baicalensis and Scutellaria lateriflora. It is one of the chemical ingredients of Sho- Saiko- To, an herbal supplement. It is also present in the bark isolate of the...
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