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  • Jinchemical Di Tert Butyl Dicarbonate - China

    price: contact company for price

    Di-tert-butyl dicarbonate is a reagent widely used in organic synthesis.

    his carbonate ester reacts with amines to give N-tert-butoxycarbonyl or

    so-called t-BOC derivatives. These derivatives do not behave as amines,

    which allows certain subsequent transformations to occur that would have

    otherwise affected the amine functional group. The t-BOC can later be

    removed from the amine using acids. Thus, t-BOC serves as a protective

    group, for instance in solid phase peptide synthesis. It is unreactive

    to most bases and nucleophiles, allowing for an orthogonal Fmoc

    protection. Protection and deprotection of amines The Boc group can be

    added to the amine under aqueous conditions using di-tert-butyl

    dicarbonate in the presence of a base such as sodium bicarbonate.

    Protection of the amine can also be accomplished in acetonitrile

    solution using 4-dimethylaminopyridine (DMAP) as the base. Removal of

    the t-BOC in amino acids can be accomplished with strong acids such as

    trifluoroacetic acid neat or in dichloromethane, or with HCl in

    methanol. A complication may be the tendency of the t-butyl cation

    intermediate to alkylate other nucleophiles; scavengers such as anisole

    or thioanisole may be used.Selective cleavage of the N-Boc group in the

    presence of other protecting groups is possible when using AlCl3. The

    use of triethylsilane as a carbocation scavenger in the presence of

    trifluoroacetic acid in dichloromethane has been shown to lead to

    increased yields, decreased reaction times, simple work-up and improved

    selectivity for the deprotection of t-butyl ester and t-butoxycarbonyl

    sites in protected amino-acids and peptides in the presence of other acid-

    sensitive protecting groups such as the benzyloxycarbonyl, 9-

    fluorenylmethoxycarbonyl, O- and S-benzyl and t-butylthio groups.

    Jinchemical Di Tert Butyl Dicarbonate

    Feel free to contact us with all your questions

    Company Contact:

    • Phone: 862586819858

    • Address: Huangtang Town, Danyang, Jiangsu Province, danyang, China

    • Email: Email

    Published date: November 1, 2012 -

    • Business Description: involved in international trade import export of goods, products, and services

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