Anti Alk R1275q Mouse Monoclonal Antibody - USA

Catalog Number: 26151

Gene Symbol: ALK, CD246, NBLST3

Description: Anti-ALK (R1275Q) Mouse Monoclonal Antibody

Background: Anaplastic lymphoma kinase (ALK) also known as CD246 (cluster of differentiation 246) is a tyrosine kinase receptor that plays an important role in the development of the brain and nervous systems.

Deficiencies in ALK, which most commonly as a fusion with other genes, are indicated in cancers.

Immunogen: A synthetic peptide from the internal region of ALK which includes the mutation of R1275Q, human origin.

Applications: ELISA, WB, IHC

Recommended Dilutions:

ELISA: 1: 1000-1: 5000

WB: 1: 100-1: 1000

IHC: 1: 50-1: 100

Concentration: 0.5 mg/ml

Host: Mouse

Format: Liquid

Clonality: Monoclonal

Isotype:

Purity: Purified from ascites

Storage buffer:

Preservative: no

Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol

Species Reactivity: Recognizes ALK (R1275Q), but not wild type ALK protein from vertebrates.

Storage Conditions: Store at -20°C.

Avoid freeze / thaw cycles

Company Contact:

• Posted By: NewEast Biosciences

• Phone: 6109452007

• Address: 24 Whitewoods Lane, Malvern , PA , USA

• Email:

• Website: http://www.neweastbio.com

• Business Description: NewEast Biosciences are specialized in generating protein configuration specific monoclonal antibodies that recognize active (GTP bound) G proteins (including Ras superfamily small GTPases and heterotrimeric G proteins).
  
  These unique antibodies do not recognize the inactive (GDP bound) G proteins.
  
  These monoclonal antibodies have been successfully used to immunoprecipitate active G proteins from cell lysates, and for immunohistochemical staining of active G proteins in cultured cells or in tissue sections.
  
  Hence, these antibodies can be used to study the spatial and temporal dynamics of cellular signaling involving big and small G proteins, the future direction of signal transduction studies.