Synphase Lanterns A Modular Solid Phase Platform As An Alternative To Resin - China

SynPhase Lanterns - a modular solid phase platform as an

alternative to resins

Characteristics of Ideal Solid Phase

1 - Equivalent Reactivity of Functional Groups

approach solution phase conditions

2 - Physicochemical Compatibility

with compounds being synthesized

with polar and non- polar solvents

3 - Good Mechanical Properties

under wide range of solvent, temperature and pressures

Why Solid Phase Synthesis?

1 - Simplifies parallel handling

2 - Readily automated

3 - Drive reactions to completion with excess reagent

4 - Remove excess: reagents and

5 - by- products by washing

Morphology of Solid Supports

Microporous gels

low cross- linked copolymers such as polystyrene ( PS) ,

polyamides ( PA) , etc.

Macroporous or macroreticular resins

controlled- pore glass or highly cross- linked polystyrene.

Pellicular supports

composed of two layers

mobile accessible surface on a solid core material

eg.

glass, PTFE ( Polytetrafluoroethene) , PP( polypropylene) or

highly cross- linked PS

Lanterns:

Launched March 2000

Adopted as library synthesis platform by several big

pharmaceutical companies

Polystyrene or Polyamide surface on polypropylene

Quantised solid phase

Can be used as Matrix Format or Direct sort format

Structure of Lantern Surface

Uniform 50 micron graft

High loading

Excellent kinetics

Temperature stability

( - 80& deg; C to 100& deg; C )

Minimal swelling

Stable to agitation

SynPhaseTM technology used in Parallel mode

Lanterns ( in white) fixed to stems ( in blue) which are fixed

to stem holder in 8x12 array format ( 96) .

This can now go

into 96 well plate each having different reaction mixtures.

The Classic MultiPinTM Method

Simple handling

Convenient 8x12 array format

Detachable stems

Ideal for washes and simultaneous cleavage

Any chemistry carried out on Resins is transferable to

Lanterns with minimum modification

Synthesis of peptide VQAAIDYING on Rink Lanterns using a CEM

DISCOVER MICROWAVE UNIT

Solution A 1.46 g HBTU in 10 mL DMF

Solution B 0.8 g HOBT in 10 mL DMF

Coupling solution

AA Production solution 0.82 mL

Solution A 0.64 mL

Solution B 0.64 mL

NMM 0.064 mL

Fundamental differences between SynPhase& trade; Lanterns and

Resins

Handling convenience

Rapid and uniform kinetics

Rapid washing

Broad applications

solid phase synthesis

parallel synthesis, tagged based techniques

solution phase synthesis

scavengers, catch and release, support bound reagents

Cost effective

Company Contact:

• Posted By: Beijing ZhogXingBoMai Co, Ltd.

• Phone: 8601082037209

• Address: Rm.1310 Tower A Huayuan Building No.32 Huayuan Eas, beijing , China

• Email:

• Website: https://biomedi.com.cn

• Business Description: Beijing ZhogXingBoMai Co, Ltd. is a company , which is specialized in
  
  producing, processing and marketing peptide products, biological
  
  laboratory equipment, healthcare equipment, microscopes and water
  
  purification system .
  
  We have a complete and scientific quality
  
  management system.
  
  The integrity, strength and product quality of
  
  Beijing Zhongxing Technology Co, Ltd. is recognized by the industry.
  
  Welcome to visit, guide and to negotiate business.