Anti Jak2 R683s Mouse Monoclonal Antibody - USA

Catalog Number: 26315

Gene Symbol: JAK2, JTK10, THCYT3

Description: Anti- JAK2 ( R683S) Mouse Monoclonal Antibody

Background: JAK2 is a non- receptor tyrosine kinase.

It is a number of the Janus kinase family and has been implicated in ssignaling by members of the type II cytokine receptor family, the GM- CSF receptor family, the gp130 receptor family, and the single chain receptors.

JAK2 orthologs have been identified in all mammals for which complete genome genome data are available.

Mutations of JAK2 have been implicated in polycythemia vera, essential thrombocythemia, and myelofibrosis as well as other myeloproliferative disorders.

Immunogen: A synthetic peptide from the internal region of JAK2 which includes the mutation of R683S, human origin.

Applications: ELISA, WB, IHC

Recommended Dilutions:

ELISA: 1: 1000- 1: 2000

WB: 1: 500- 1: 1000

IHC: 1: 50- 1: 100

Concentration: 0.5 mg/ ml

Host: Mouse

Format: Liquid

Clonality: Monoclonal

Isotype:

Purity: Purified from ascites

Storage buffer:

Preservative: no

Constituents: PBS ( without Mg2+ and Ca2+) , pH 7.4, 150 mM NaCl, 50% glycerol

Species Reactivity: Recognizes R683S mutant, but not wild- type JAK2 of vertebrates.

Storage Conditions: Store at - 20°C.

Avoid freeze / thaw cycles

Company Contact:

• Posted By: NewEast Biosciences

• Phone: 6109452007

• Address: 24 Whitewoods Lane, Malvern , PA , USA

• Email:

• Website: http://www.neweastbio.com

• Business Description: NewEast Biosciences are specialized in generating protein configuration specific monoclonal antibodies that recognize active (GTP bound) G proteins (including Ras superfamily small GTPases and heterotrimeric G proteins).
  
  These unique antibodies do not recognize the inactive (GDP bound) G proteins.
  
  These monoclonal antibodies have been successfully used to immunoprecipitate active G proteins from cell lysates, and for immunohistochemical staining of active G proteins in cultured cells or in tissue sections.
  
  Hence, these antibodies can be used to study the spatial and temporal dynamics of cellular signaling involving big and small G proteins, the future direction of signal transduction studies.